Protein Modification Reagents
Sigma Aldrich Fine Chemicals Biosciences SIGMA ALDRICH FINE CHEMICALS BIOSCIENCES
NC3976101 COLLAGENASE HYALURONIDASE BLND
Medchemexpress LLC DBCO-PEG2-DBCO | 2639395-48-3 | C44H42N4O6 | 25 MG
DBCO-PEG2-DBCO is a click chemistry reagent that contains a DBCO group. It functions as a PEG linker with two terminal DBCO groups. These DBCO groups are frequently used for copper-free Click Chemistry reactions due to their strain-promoted high energy. The hydrophilic PEG chain in DBCO-PEG2-DBCO enhances its water solubility. This product is reagent grade and intended for research use only.
- Contains a DBCO group
- Functions as a PEG linker with two terminal DBCO groups
- Commonly utilized in copper-free click chemistry reactions
- Exhibits strain-promoted high energy
- Hydrophilic PEG chain enhances water solubility
- Reagent grade
- Intended for research use only
Medchemexpress LLC PROTAC STING Degrader-1 | 2762552-74-7 | C34H33N7O10 | 1 MG
PROTAC STING Degrader-1 is a PROTAC degrader targeting the STING pathway with a DC50 of 3.2 μM. It demonstrates high anti-inflammatory efficacy and can be utilized for studying conditions such as acute kidney injury and inflammatory bowel diseases (IBDs). The compound consists of a STING ligand, a CRBN ligand, and a linker.
- Degrades STING in a dose- and time-dependent manner
- Downregulates downstream signals of the STING pathway
- Shows no cytotoxicity in LO2, HEK293A, and C17.2 at doses below 10 μM
- Alleviates ischemic symptoms and reduces kidney weights in acute kidney injury models
- Ameliorates the severity of DSS-induced colitis
- Reduces the production of proinflammatory cytokines and transcription of ISGs
Cayman Chemical Humn GastrIc InhIbItry Poly 96
This assay kit provides the convenience of an all-inclusive cell-based reporter assay. In addition to GIPR Reporter Cells, provided are two optimized media for use in recovering the cryopreserved cells and for diluting test samples, the reference activator GIP, Luciferase Detection Reagents, and a cell culture-ready assay plate
Supply Solutions Sigma Aldrich - Collagenase B, 2.5g, non-sterile * Third Party Item
Sigma Aldrich - Collagenase B, 2.5g, non-sterile * Third Party Item
Medchemexpress LLC Pomalidomide-peg4-c2-nh2 hydrochloride | 2357105-92-9 | 98.2% | 528.98 | 1 G
Pomalidomide-PEG4-C2-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a 4-unit PEG linker, used in the synthesis of PROTACs. It is for research use only and not sold to patients.
- PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein.
- PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- These methods are for reference only.